In general, the element magnesium reduces production of TNF. It is not clear if this effect carries over to animals infected with H5N1 or other viruses.

• In macrophages stimulated by bacterial LPS, TNF secretion was enhanced in a low magnesium environment and inhibited in a high magnesium environment. (PMID:12892381 (cache), PMID:12635866 (cache))

• Magnesium depletion has been shown to increase TNF and Substance P levels in the blood of rats fed an extremely low magnesium diet. (14704297 (cache), 9989243 (cache)).

One problem with magnesium is that a therapeutic dose may cause diarrhea; although H5N1 is considered an influenza (respiratory) virus, it can also cause gastrointestinal symptoms including diarrhea. In general, chelated forms of magnesium are less likely to cause bowel problems than simpler forms like magnesium oxide. It has been shown that significant amounts of magnesium can be absorbed through the skin (1-2 pounds epsom salt per bath, or epsom salt packs on the skin, which can be drying).

Perhaps the best strategy for preparing for an acute illness is to remedy sub-optimal magnesium levels before the infection occurs. A moderate supplement of magnesium over a long period of time is less likely to have any adverse effects than a sudden large increase in the electrolyte.

Those with heart or kidney problems are strongly advised to consult their doctor before begining a magnesium supplement. Although magnesium can be beneficial for some heart and kidney conditions, it can complicated others.



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